ANTIcoagulation in Severe COVID-19 Patients

Exclusion Criteria

• •Pregnancy and breast feeding woman;
• •Postpartum (6 weeks);
• •Extreme weights (\<40 kg or \>100 kg);
• •Patients admitted since more than 72 hours to the hospital (if the WHO ordinal scale is 5 at time of inclusion) or since more than 72 hours to the intensive care unit (if the WHO ordinal scale is 6 or more at time of inclusion);
• •Need for therapeutic anticoagulation (except for COVID-related pulmonary thrombosis);
• •Bleeding event related to hemostasis disorders, acute clinically significant bleed, current gastrointestinal ulcer or any organic lesion with high risk for bleeding
• •Platelet count \< 50 G/L;
• •Within 15 days of recent surgery, within 24 hours of spinal or epidural anesthesia;
• •Any prior intracranial hemorrhage, enlarged acute ischemic stroke, known intracranial malformation or neoplasm, acute infectious endocarditis;
• •Severe renal failure (creatinine clearance \<30 mL/min);
• •Iodine allergy;
• •Hypersensitivity to heparin or its derivatives including low-molecular-weight heparin;
• •History of type II heparin-induced thrombocytopenia;
• •Chronic oxygen supplementation;
• •Moribund patient or death expected from underlying disease during the current admission;
• •Patient deprived of liberty and persons subject to institutional psychiatric care;
• •Patients under guardianship or curatorship;
• •Participation to another interventional research on anticoagulation.