Clareo Health | Study to Evaluate the Safety and How the Body Handles a Single Dose of Subcutaneous (SC) and Intravenous (IV) Budigalimab in Adult Participants Living With Human Immunodeficiency Virus (HIV)
Study to Evaluate the Safety and How the Body Handles a Single Dose of Subcutaneous (SC) and Intravenous (IV) Budigalimab in Adult Participants Living With Human Immunodeficiency Virus (HIV)
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
AbbVie
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Condition of generally good health, body mass index ≥ 18.0 to \< 35.0 kg/m2.
Laboratory values must meet acceptable criteria.
Human Immunodeficiency Virus (HIV-1) infected on antiretroviral therapy (ART) for at least 12 months prior to screening and on current ART regimen for at least 8 weeks prior to screening.
CD4 cell count ≥ 450 cells/μL at Screening and during the 12 months prior to Screening.
Plasma HIV-1 RNA below the lower limit of quantification at Screening and at least 6 months prior to Screening.
Participants agreeing to use an effective barrier method of protection (male and/or female condom) during sexual activity from Study Day 1 through last study visit for the purposes of prevention of HIV transmission.
You may not be if
Participants with signs/symptoms associated with SARS-CoV-2 infection OR Current SARS-CoV-2 infection by any viral nucleic acid test completed within 7 days prior to the Day 1 dose.
Participants having history or ongoing diagnosis of acquired immunodeficiency syndrome (AIDS)-defining illness.
Participants having history of or active immunodeficiency (other than HIV).
Participants having active autoimmune disease or history of autoimmune disease that has required systemic treatment.
Prior therapy/exposure to budigalimab or any other immune checkpoint inhibitor \[e.g., anti-programmed cell death protein 1(PD-1), anti-PD-L1, anti-PD-L2, anti-CTLA4\].
Participants having clinically significant medical disorders that might expose the subjects to undue risk of harm, confound study outcomes, or prevent the subject from completing the study.
Participants having active or suspected malignancy or history of malignancy (other than basal cell skin cancer or cervical carcinoma in situ) in the past 5 years.
Participants with history of or active tuberculosis (TB) at screening.
Participants having known psychiatric or substance abuse disorders that would interfere with adherence to study requirements.
Participants who have received immunomodulatory or immunosuppressive (including IV/orally administered \[PO\] steroids at any dose, but excluding steroids that are inhaled, topical or via local injection) therapy within 24 weeks prior to the first dose of study drug.
