Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Brigham and Women's Hospital
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Criteria:
Please see https://www.bwhprime.org/resources.html for full code and algorithm definitions.
Eligible cohort entry dates:
For US MarketScan, 2012-2018
For Optum, 2012-2020
For Medicare Claims Database (Parts A, B and D), 2012-2017
Cohort entry date:
First TNFi or tofacitinib dispensation/administration date
* Patients treated with tofacitinib or TNF inhibitors in IBM MarketScan, Optum, and Medicare fee-for-service
* A minimum of 365 days of continuous enrollment in health plan prior to (and including) the cohort entry date
* Two diagnosis codes for RA in any setting in 365 days baseline period (diagnosis codes between 7 and 365 days apart)
Patients with at least one methotrexate dispensation (six months look-back period)
Patients with at least one cardiovascular risk factor (including smoking, hypertension, dyslipidemia, diabetes mellitus, ischemic heart disease, family history of ischemic heart disease) (one-year look-back period)
You may not be if
* Index drug in 365 days prior to cohort entry date (prevalent users)
* Missing data on age or gender
* Admission to nursing facility or hospice on or prior to cohort entry date (ever look-back)
* Diagnosis of malignant cancer prior to cohort entry date (ever look-back period)
* TNFi users with history of any Janus kinase (JAK) inhibitors (tofacitinib, upadacitinib, or baricitinib) (ever look-back period)
* TNFi users initiating with more than one TNFi on same date
* Tofacitinib users with a prescription of baricitinib, upadacitinib (ever look-back period)
* Tofacitinib users initiating treatment on multiple JAK inhibitors on same day (tofacitinib and baricitinib, tofacitinib and upadacitinib)
Patients less than 18 years of age (MarketScan and Optum) and 65 years of age (Medicare) at cohort entry
Patients less than 50 years of age (MarketScan and Optum) and 65 years
Patients recently hospitalized with infections (30-day look-back period)
