Systems Biology of Early Atopy

This is a prospective cohort study in which pregnant women (at any stage of pregnancy), the offspring's biologic father, and the offspring will be enrolled at study sites, and the offspring will be observed from birth to age 3 years. Enrollment of biological fathers will be attempted; however, enrollment of the mother or child is not dependent on enrollment of the biological father. The enrollment goal is at least 2500 mothers and their offspring having reached 12 months on study. Additionally, families will be offered the opportunity for the child participant to continue SUNBEAM through age 6 via the SUNBEAM II continuation protocol. During the study, biological and environmental samples and questionnaire information will be collected from the parents and the children, and the children will be assessed for allergic diseases at clinic visits at ages 2, 5, 12, 24, and 36 months and for those who opt to continue participation, at 48, 60, and 72 months.