A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of JS004 in Advanced Solid Tumors

Exclusion Criteria

• •Patients will be excluded from the study when they have any of the following conditions:
• •1. History of malignant tumors other than the disease investigated in the past 5 years, however, except for the malignant tumors that can be expected to be cured after treatment;
• •2. Having received systematic antitumor therapy, or local antitumor therapy, or treatment with clinically investigational medication or device within 4 weeks prior to the first dose of study drug;
• •3. Having received immunotherapy within 4 weeks prior to first dose of study drug;
• •4. Previously treated with anti-BTLA or anti-HVEM antibody;
• •5. Adverse reaction induced by previous therapy having not recovered to CTCAE (version 5.0) grade 1 or better;
• •6. Having previously received allogeneic hematopoietic stem cell transplantation or solid organ transplantation;
• •7. Having central nervous system metastases and/or cancerous meningitis;
• •8. Having or suspected to have active autoimmune disease;
• •9. Having hepatitis and liver cirrhosis;
• •10. Massive hydrothorax or ascites with clinical symptoms or requiring symptomatic treatment;
• •11. Having severe cerebro- and cardiovascular diseases;
• •12. Having pulmonary disease;
• •13. Having active infection requiring systemic treatment;
• •14. Positive result for human immunodeficiency virus (HIV) antibody;
• •15. Active hepatitis B or C;
• •16. Known active tuberculosis (TB);
• •17. Use of systemic corticosteroids 14 days prior to the first dose of study drug;
• •18. Use of broad-spectrum antibiotics that may affect the change of intestinal flora within 14 days prior to the first dose of study drug;
• •19. Vaccination of live vaccine within 4 weeks prior to the first dose of study drug;
• •20. Having received major surgery within 4 weeks prior to the first dose of study drug;
• •21. History of anti-psychotics abuse and unable to abstain, or with a history of mental disorder;
• •22. Pregnant or breast-feeding women;
• •23. Known allergy to JS004 and its components;
• •24. Other severe, acute or chronic medical conditions or mental diseases or laboratory abnormalities possibly increasing relevant risks in participation in the study or possibly interfering with the interpretation of study results as judged by investigators.