Evaluation of EndoZip System in Obese Patients Who Failed to Reduce Weight With Non-surgical Weight-loss Methods

study will include up to 45 (10-20 patients per site), ages of 21 -70 of obese patients who failed to reduce weight with non-surgical weight-loss methods. The duration for each participant will be 12 months and will include the following follow up visits and procedures: * Office visits: screening, 1 week, and 1, 2, 4, 6, 8, 10, and 12 month(s) * Remote follow up (by Phone): 3, 5, 7, 9, and 11 month(s) * Endoscopy procedure: baseline, 2 and 6 months post EndoZip procedure * Motility evaluation by Gastric Emptying Breath Test (GEBT): baseline, 6 months * Physical examination, vital signs, waist circumference and BMI: baseline, 1 week, 1, 2, 4, 6, 8, 10 and 12 months * Blood tests: baseline,2, 6 and 12 months * IWQOL-Lite: baseline, 2, 6 and 12 months * Psychological health questionnaire-9 (PHQ-9) :baseline * Sleep Apnea (only for the relevant population): baseline 2, 6 and 12 months The patient will required to follow a specific diet and to have a physical activity during the study period ( 12 month).