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Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®). | Clinical Trials | Clareo Health

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Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).

Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study.

NCT04767243•Maharishi Markendeswar University (Deemed to be University)

View on ClinicalTrials.gov

Summary

The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis patients.

Detailed Description

45 sites with vertical intrabony alveolar defects will be selected. These defect sites will be allocated randomly into 3 groups as Group I, Group II and Group III. * Group I will be treated with open flap debridement and filled with A-PRF * Group II will be treated with open flap debridement and filled with Bioactive glass (Perioglas®) * Group III will be treated with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.

Eligibility

Age

25 - 55 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age: 25 to 55 years.
•Gender: Both males and females will be included in the study.
•Co-operative and motivated patients committed to oral hygiene.
•Patients exhibiting intrabony defects.

Exclusion Criteria

•Patients with contraindication to periodontal surgery \& local anesthesia.
•Any systemic disease affecting the bone density and outcome of periodontal therapy.
•Smokers, alcoholics, and patients with other adverse habits.
•Pregnant, nursing and menopausal women.
•Any known allergy/ hypersensitivity to any product used in this study.
•Patients on long-term systemic therapy (antibiotics, anti-inflammatory bisphosphonates, hormonal replacement therapy and any other), taking any drug known to have periodontal implications that may interfere with wound healing.
•Patients taking any anti-platelet and anticoagulant medication.
•Patients who have undergone periodontal treatment within a period of past 1 year.

Locations (1)

Department of Periodontology, M.M. College of Dental Sciences and Research.

Ambāla, Haryana, India

Key Dates

Start Date

December 1, 2020

Primary Completion Date

February 18, 2022

Completion Date

March 4, 2022

Last Updated

November 8, 2022

Enrollment

ACTUAL participants

Conditions

Chronic PeriodontitisBone LossIntrabony Periodontal Defect

Interventions

open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin)

PROCEDURE

open flap debridement and filled with Bioactive glass (Perioglas®)

PROCEDURE

open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF

DRUG

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RECRUITINGNA

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 8, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).

Inclusion Criteria

Exclusion Criteria

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Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment

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