Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates

Exclusion Criteria

• •Personal or family History of significant medical illness
• •Clinically significant abnormalities on screening tests/exams
• •History of or significant risk of committing suicide
• •Donation of plasma within 7 days prior to dosing
• •Donation or significant loss of blood within 30 days prior to the first dosing
• •Major surgery within 3 months or minor surgery within 1 month prior to admission
• •Use of prohibited prescription, over-the-counter medications or natural health products
• •Alcohol-based products 24 hours prior to admission
• •Female subjects who are currently pregnant or lactating
• •Positive pregnancy test
• •Use of tobacco or nicotine products within 3 months prior to Screening
• •Significant alcohol consumption
• •History of drug abuse within the previous 2 years, or a positive drug screen
• •History of allergy to study medications
• •Undergoing abrupt discontinuation of alcohol or sedatives
• •Not suitable for study in the opinion of the Principal Investigator