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COLON MD: Colon Cancer Longitudinal Study of the Microbial Metabolites and Dietary Factors That Influence Response to Treatment
The goal of this proposal is to identify how the composition of the gut microbiome and diet interact to impact chemotherapy-induced diarrhea incidence and severity.
In this longitudinal observational study patients will supply samples of their gut microbiome prior to scheduled colonoscopy or surgery along with dietary intake and blood samples; the relative abundance of microbes from those samples along with dietary data will be used to predict the presence or absence and severity of chemotherapy-induced diarrhea. Microbiome and diet based predictions from blinded samples will be combined to map the diet-microbiome changes during treatment to the changes in immune markers and risk of chemotherapy-induced diarrhea.
Age
18 - 79 years
Sex
ALL
Healthy Volunteers
No
Baylor Research Institute
Temple, Texas, United States
Start Date
February 1, 2021
Primary Completion Date
June 1, 2026
Completion Date
June 1, 2026
Last Updated
January 26, 2026
11
ESTIMATED participants
Lead Sponsor
Baylor Research Institute
Collaborators
NCT04704661
NCT04674267
Data Source & Attribution
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