Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALS

Inclusion Criteria

• •1. Have the ability to understand the requirements of the study, provide written informed consent, understand and provide written authorization for the use and disclosure of Protected Health Information (PHI) \[per Health Insurance Portability and Accountability Act (HIPAA) Privacy Ruling\] and comply with the study procedures.
• •2. Men and women at least 18 years old.
• •3. Women must have a negative serum pregnancy test and practice an acceptable method of contraception or be of non-childbearing potential (post-menopausal for at least 2 years or who have undergone hysterectomy, oophorectomy or surgical sterilization).
• •4. Geographic accessibility to the study center and the ability to travel to the clinic for study visits.
• •5. Presence of a willing and able caregiver.
• •6. Diagnosis of ALS based on examination by the site PI, meeting El Escorial criteria for possible, laboratory-supported probable, probable or definite ALS or be a person without a diagnosis of ALS disorder
• •7. Vital capacity ≥ 50% of predicted normal for age, height and gender measured in the seated position and the ability to lie supine for a period of 1 hour.
• •8. Agrees to the visit schedule as outlined in the informed consent.
• •9. Pre-study labs within normal range, or if abnormal, deemed not clinically significant by the site investigator.