Oxidative Stress Markers in COPD

Chronic Obstructive Pulmonary Disease in Non Smokers:Role of Oxidative Stress

NCT04748887•Minia University

Summary

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Eligibility

Age

All ages

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control

Exclusion Criteria

•Patients of:
•1. Acute exacerbation, at the time of the study, of COPD.
•2. Any obvious abnormal lung parenchymal lesions.
•3. Lung cancer.
•4. Congestive heart failure.
•5. current smokers
•6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

Locations (1)

Minia University Hospital

Multiple Locations, Minya Governorate, Egypt

Key Dates

Start Date

September 1, 2018

Primary Completion Date

April 1, 2019

Completion Date

September 1, 2019

Last Updated

February 10, 2021

Enrollment

ACTUAL participants

Conditions

Role of Oxidative Stress in COPD

Interventions

oxidative stess markers

OTHER