Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments

Exclusion Criteria

• •Patient (≥18 years old) or legally authorized representative didn't provide informed consent. Delayed informed consent can be applied in cases where the patient is critically ill and no LAR is available.
• •antibiotic administration as a single dose or as a prophylactic treatment.
• •antibiotics administered without an accompanying body fluid culture according to the timeframe (within 6 hours after emergency department presentation).
• •'Do no intubate' or 'comfort measures only' status.
• •Failure to randomize within 6 hours after Emergency Department presentation.
• •Weight \< 45 kg.
• •Pregnant or breastfeeding.
• •Known allergy for Vitamin C.
• •Known history of oxalate nephropathy or hyperoxaluria.
• •Known history of glucose-6-phosphate dehydrogenase deficiency.
• •Known history of chronic iron overload due to iron storage and other diseases.
• •The patient is already on IV steroids for a reason other than septic shock.
• •Proven active COVID-19 infection (positive swab and/or CT scan positive for COVID-19 within 14 days prior to or at ED presentation).
• •Participation in an interventional trial with an investigational medicinal product (IMP) or device