A Study of Different Forms of TAK-994 in Healthy Adults

Exclusion Criteria

• •1. Mentally or legally incapacitated or has significant emotional problems at the time of the screening visit or expected during the conduct of the study.
• •2. Current or past history of epilepsy, seizure, or convulsion, tremor, or related symptoms.
• •3. Positive urine drug or alcohol results at screening or check-in.
• •4. Positive results at screening for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV).
• •5. Consumes excessive amounts, defined as greater than 4 servings (1 serving is approximately equivalent to 120 mg of caffeine), of coffee, tea, cola, energy drinks, or other caffeinated beverages per day.
• •6. Has been on a diet incompatible with the on-study diet, in the opinion of the Investigator or designee, within the 30 days prior to the first dosing and throughout the study.
• •7. Is lactose intolerant or unable/unwilling to eat the high-fat/high-calorie breakfast.
• •8. Donation of blood or significant blood loss within 56 days prior to the first dosing.
• •9. Plasma donation within 7 days prior to the first dosing.
• •10. Participation in another clinical study within 30 days or 5 half-lives (whichever is longer) prior to the first dosing. The 30-day window or 5 half-lives will be derived from the date of the last blood collection or dosing, whichever is later, in the previous study to Day 1 of Period 1 of the current study.