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In-hospital Versus After-discharge Complete Revascularization | Clinical Trials | Clareo Health

COMPLETEDNA

In-hospital Versus After-discharge Complete Revascularization

In-hospital Versus After-discharge Complete Revascularization in STEMI Patients With Multivessel Disease.

NCT04743154•Hospital General Universitario de Valencia

Summary

Patients with STEMI and multivessel disease in whom the culprit lesion has been successfully revascularized during prmimary PCI, will be randomized to in-hospital or after-discharge complete revascularization. The purpose of this study is to evaluate the impact of these two different strategies in terms of hospital stay.

Detailed Description

STEMI patients with mutivessel disease are, after successful primary angioplasty, randomized 1:1 ratio to either in-hospital complete revascularization or after-discharge complete revascularization strategy. Eligible non-culprit coronary arteries must be \>2.0 mm in diameter and at the discretion of the operator suitable for PCI. Only arteries with angiographically stenoses ≥70% or between ≥50% and \<70 in proximal segments can be randomized. Patients in the in-hospital revascularization group will undergo to non-culprit percutaneous coronary intervention (PCI) at least 24 hours after ST-segment elevation myocardial infarction. On the other hand, patients in the after-discharge group will undergo to non-culprit PCI within 4-6 weeks after STEMI.

Eligibility

Age

18 - 90 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Acute onset of chest pain \<12 hours duration.
•ST-segment elevation ≥ 0.1 millivolt in ≥ 2 contiguous leads, signs of a true posterior infarction or documented newly developed left bundle branch block.
•Culprit lesion in a major native vessel, with successful primary PCI.
•Presence of at least one non-culprit lesion more than or equal to 70% of stenosis in a vessel more than 2mm of diameter or more than or equal to 50% stenosis in proximal segments.
•The patient is able to give written consent for participation in the study.

Exclusion Criteria

•Pregnancy.
•Significant left main stenosis.
•Stent thrombosis.
•Chronic total occlusion.
•Severe stenosis of non-culprit vessels with distal flow less than TIMI3.
•Significant non-culprit stenosis no candidate to revascularization.
•Presence of valvulopathy candidate for cardiac surgery.
•Cardiogenic shock status at admission.
•The patient is not able to give written consent for participation in the study.

Locations (1)

Hospital General Universitario de Valencia

Valencia, Spain

Key Dates

Start Date

January 20, 2018

Primary Completion Date

November 25, 2021

Completion Date

December 21, 2022

Last Updated

April 24, 2023

Enrollment

250

ACTUAL participants

Conditions

STEMI - ST Elevation Myocardial InfarctionMultivessel Coronary Artery Disease

Interventions

In-hospital nonculprit-lesions percutaneous coronary intervention (PCI)

OTHER

After-discharge nonculprit-lesions percutaneous coronary intervention (PCI)

OTHER

SuperSaturated Oxygen Comprehensive Observational Registry

NCT06438315

STEMI - ST Elevation Myocardial InfarctionAMI

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RECRUITINGNA

Revascularization Strategies in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) and Severe Coronary Artery Disease

NCT01311323

Multivessel Coronary Artery DiseaseAcute Coronary Syndrome

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 24, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

In-hospital Versus After-discharge Complete Revascularization

Inclusion Criteria

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