Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study

PRIMARY OBJECTIVES: I. Demonstrate ability to monitor cancer-specific deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and proteomic alterations from plasma. II. Improve detection of recurrences post completion of curative therapies through monitoring of plasma cancer-specific DNA, RNA and proteomic alterations. SECONDARY OBJECTIVES: I. Qualitative and quantitative changes in cancer-specific plasma alterations during neoadjuvant, adjuvant therapies and surveillance. II. Disease free survival (DFS) of patients with detectable cancer-specific plasma alterations. III. Overall survival (OS) of patients with detectable cancer-specific plasma alterations. EXPLORATORY OBJECTIVES: I. Optimal combination of cancer-specific plasma DNA, RNA and / or proteomic alterations for early detection of recurrences. II. Sensitivity, specificity, positive predictive and negative predictive values of cancer-specific plasma alterations in detecting recurrences. III. Correlation between cancer-specific alterations in plasma and tissue and either with outcomes including DFS \& OS. IV. Nature and frequency of detection of incidental non-colorectal cancer related DNA, RNA and / or proteomic alterations. OUTLINE: Patients undergo collection of blood samples at baseline, during each neoadjuvant therapy treatment, prior to surgical resection, and up to 4 times per year for up to 5 years. Patients also undergo collection of tissue sample at time of surgical resection. Patients' medical records may also be reviewed.