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Active Not RecruitingPhase 2NCT04727658

Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL)

Radiosurgical thalamotomy on GammaKnife has been shown to be effective in the management of tremors. However, several teams describe a significant risk of severe neurological complications. In additio...

Lead sponsor: Centre Hospitalier Universitaire de Nice•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Centre Hospitalier Universitaire de Nice

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•patient with disabling essential tremor, dystonic and / or parkinsonian in one or more limbs superiors ;
•patient contraindicated or refusing deep brain stimulation ;
•patient ≥ 18 years old,
•women of childbearing potential must take effective contraception ;
•signature of informed consent ; p- atients who benefited from contralateral thalami c stimulation can be included in the study

Exclusion Criteria

•brain irradiation history ;
•contraindication or inability to perform injected MRI ;
•life expectancy \<12 months ;
•claustrophobic patient who cannot stand the radiotherapy mask ;
•abnormal anatomy of the thalamic region ;
•treatment with a trial drug within 30 days of entering the study ;
•presence of medical, psychological, social or geographic factors likely to modify the patient's compliance with the protocol under study or the monitoring or signing of the consent

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 8, 2025Terms

Trial snapshot

StatusACTIVE_NOT_RECRUITING

PhasePHASE2

Enrollment9

Start dateJul 2021

Last updatedDec 8, 2025

Condition

Essential Tremor Parkinsonian Disorders

Locations shown

Centre Hospitalier Princesse Grace

Monaco

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 8, 2025Data synced to Clareo: May 17, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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