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Recent exploratory studies suggest that pacemaker patients with diastolic dysfunction (DD) or heart failure with preserved ejection fraction (HFpEF) may benefit from a higher backup heart rate (HR) setting than the factory setting of 60 beats per minute (bpm). In this prospective double-blinded randomized controlled study, pacemaker patients with DD or overt HFpEF and either 1) intrinsic ventricular conduction or 2) conduction system or biventricular pacing will be enrolled and randomized to either a personalized lower HR setting (myPACE group, based on a height-based HR algorithm) or to the standard 60bpm backup setting (control group) for 1 year.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
University of Vermont Medical Center
Burlington, Vermont, United States
Start Date
July 17, 2019
Primary Completion Date
October 30, 2021
Completion Date
December 5, 2021
Last Updated
February 9, 2022
123
ACTUAL participants
Adjustment of lower rate limit
DEVICE
Maintenance of lower rate limit
DEVICE
Lead Sponsor
University of Vermont
NCT07480265
NCT05064709
Data Source & Attribution
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