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SHAPE of Portal Hypertension in Children | Clinical Trials | Clareo Health

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RECRUITINGPhase 2NCT04720456

SHAPE of Portal Hypertension in Children

Early diagnosis of portal hypertension is difficult as symptoms rarely manifest until the later stages of liver disease. Both cirrhotic and non-cirrhotic portal hypertension can result in life-threate...

Lead sponsor: Thomas Jefferson University•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Morgan L Gabbert, MA

CONTACT

267-426-0820 gabbertm@email.chop.edu

Sponsors

Lead Sponsor

Thomas Jefferson University

Collaborators

Children's Hospital of Philadelphia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Age

6 - 21 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patients with a diagnosis of chronic liver disease without portal hypertension.
•Patients with a diagnosis of chronic liver disease with portal hypertension.

Exclusion Criteria

•Subjects who are pregnant.
•Patients with known or suspected hypersensitivity to egg phosphatidyl serine or with a history of anaphylactic allergy to eggs or egg products.
•Subjects with allergy to egg products or other components of the ultrasound contrast agents will be excluded.
•History of allergic reaction to Lumason®, sulfur hexafluoride, sulfur hexafluoride lipid microsphere components, or other ingredients in Lumason (polyethylene glycol, distearoylphosphatidylcholine (DSPC), dipalmitoylphosphatidylglycerol sodium (DPPG-Na), palmitic acid)
•History of allergic reaction to Sonazoid
•Patients with biliary atresia with asplenia or polysplenia.
•Patients with prior liver transplant.
•Patients with cystic fibrosis.
•Patients with chronic lung disease.
•Patients with portal vein thrombosis, cavernous transformation of the portal vein or absent portal vein.
•Adults not competent/impaired.
•Patients with significant heart disease or severe congenital heart disease

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 11, 2025Terms

Trial snapshot

StatusRECRUITING

PhasePHASE2

Enrollment120

Start dateNov 2021

Last updatedFeb 11, 2025

Condition

Hypertension, Portal

Locations shown

The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 11, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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