National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
6–21
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with a diagnosis of chronic liver disease without portal hypertension.
Patients with a diagnosis of chronic liver disease with portal hypertension.
You may not be if
Subjects who are pregnant.
Patients with known or suspected hypersensitivity to egg phosphatidyl serine or with a history of anaphylactic allergy to eggs or egg products.
Subjects with allergy to egg products or other components of the ultrasound contrast agents will be excluded.
History of allergic reaction to Lumason®, sulfur hexafluoride, sulfur hexafluoride lipid microsphere components, or other ingredients in Lumason (polyethylene glycol, distearoylphosphatidylcholine (DSPC), dipalmitoylphosphatidylglycerol sodium (DPPG-Na), palmitic acid)
History of allergic reaction to Sonazoid
Patients with biliary atresia with asplenia or polysplenia.
Patients with prior liver transplant.
Patients with cystic fibrosis.
Patients with chronic lung disease.
Patients with portal vein thrombosis, cavernous transformation of the portal vein or absent portal vein.
Adults not competent/impaired.
Patients with significant heart disease or severe congenital heart disease
