Brain Changes in Psoriasis After Secukinumab Treatment

Inclusion Criteria

• •Inclusion:
• •1. Between 18 and 65 years of age.
• •2. Psoriasis patients (with/without psoriatic arthritis): Psoriasis Area (BSA) is more than 5%.
• •3. Psoriasis patients must have had a TB test in the past 8 months (if a patient has not had one, the study will provide one).
• •4. Healthy subjects: in general, good health without history of neurological and psychiatric diseases. No chronic itch, pain, skin or systemic conditions currently or in the past.
• •5. Women of child bearing potential will be administered a pregnancy test to verify that they are not pregnant.
• •6. MRI Compatibility: No major contraindication for MRI (pacemaker, vascular stents, metallic ear tubes, and absence of metal implants or braces) as assessed by MRI technologist using site approved screening form.
• •7. Participants have to be able to speak and read English fluently.
• •8. Participants must have signed a written informed consent before being enrolled in the study
• •Exclusion:
• +24 more criteria