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The EBC Recovery Study | Clinical Trials | Clareo Health

RECRUITING

The EBC Recovery Study

Electrophysiologic Biomarkers of Consciousness (EBC) Recovery After Brain Injury

NCT04712591•University of Miami

Summary

The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up in the future.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•For ABI Participants
•ABI adult (18 years and older) patients who are admitted to the intensive care unit
•Unconscious with Glasgow Coma Scale (GCS) \<8 on presentation and unable to follow bedside commands.
•A negative COVID-19 test on arrival
•For Healthy Volunteers:
•18 years and older

Exclusion Criteria

•For All Participants:
•\<18 years of age
•Pregnant woman
•Patients with cardiac arrest on presentation

Locations (2)

Jackson Memorial Hospital

Miami, Florida, United States

Columbia University

New York, New York, United States

Key Dates

Start Date

June 18, 2020

Primary Completion Date

January 1, 2030

Completion Date

January 1, 2030

Last Updated

September 4, 2025

Enrollment

300

ESTIMATED participants

Conditions

Traumatic Brain InjuryIntracerebral HaemorrhageSubarachnoid Haemorrhagic Stroke

Interventions

Auditory stimuli

DIAGNOSTIC_TEST

Contacts

Ayham Alkhachroum, MD

CONTACT

(305) 243-3218 axa2610@med.miami.edu

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 4, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The EBC Recovery Study

Inclusion Criteria

Exclusion Criteria

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Hemodynamic ABI Monitor

Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

Carbon Dioxide Administration and Brain Waste Clearance

Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury