Synuclein-One Study

Exclusion Criteria

• •Clinical evidence of severe vascular disease (history of ulceration, poor wound healing, vascular claudication)
• •Clinically active coronary artery or cerebrovascular disease
• •Current smoker or alcoholism
• •History of allergic reaction to local anesthesia for skin biopsies
• •Use of blood thinners (aspirin or Plavix alone is allowed)
• •Significantly impaired wound healing or history of scarring or keloid formation
• •Healthy individuals or individuals with synucleinopathy is disease may be explained by other causes: recent history of encephalitis, Cortical dementia of Alzheimer's type, Whipple's disease, toxin exposure, repeated head injury and stepwise disease progression suggestive of vascular etiology