A Trial of HR021618 in Postsurgical Pain Management

Exclusion Criteria

• •1、 Sufficient pain to require IVanalgesia assessed by NRS ranging 2、 No evidence of organ insufficiency, or any other abnormality, during or following surgery
• •1. History of major surgery
• •2. History of active or high-risk bleeding disorders
• •3. History of myocardial infarction or coronary artery bypass
• •4. History or clinical manifestations of significant renal, hepatic, cardiovascular, metabolic, neurologic, psychiatric, or other condition that would preclude participation in the study
• •5. Abnormal values in the laboratory
• •6. Have a known allergy to meloxicam or any excipient of HR021618, , aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs) or to any peri- or postoperative medications used in this study
• •7. Use other drugs that affect the analgesic effect before randomization, and the time from the last use to randomization is shorter than 5 half-lives
• •8. Planned/actual admission to the intensive care unit
• •9. Pregnant or nursing women
• •10. No birth control during the specified period of time
• •11. Participated in clinical trials of other drugs (received experimental drugs)
• •12. The inestigators determined that other conditions were inappropriate for participation in this clinical trial