Human Challenge Study to Evaluate the Efficacy of MV-012-968 Vaccine

Exclusion Criteria

• •1. History of symptoms or signs suggestive of upper or lower respiratory tract infection within 4 weeks prior to the first study visit
• •2. Rhinitis which is clinically active
• •3. History of moderate to severe rhinitis
• •4. Acute sinusitis during Screening
• •5. Use of corticosteroid in respiratory tract (e.g. nasal or inhaled steroid) in the 30 days leading up to study vaccination
• •6. Females who are breastfeeding or have been pregnant within 6 months prior to the study
• •7. Participants who have smoked ≥ 10 pack years at any time \[10 pack years is equivalent to one pack of 20 cigarettes a day for 10 years\])
• •8. Positive human immunodeficiency virus (HIV), active hepatitis A (HAV), B (HBV), or C (HCV) test
• •9. Those employed or immediate relatives of those employed at hVIVO or the Sponsor
• •10. Participants may not live or work in direct close contact with, or live with anyone whose work brings them into direct close contact with, children under 2 years of age
• •11. Any other finding that, in the opinion of the Investigator, deems the participant unsuitable for the study