Cambridge University Hospitals NHS Foundation Trust
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
1. Being able to provide a written informed consent
2. Age between 18 and 65 years
3. Body Mass Index (BMI) ≥25 kg/m2 and \<30 kg/m2 for non-Asian individuals and BMI≥23 kg/m2 and \<25 kg/m2 for Asian individuals according to the BMI classification by the World Health Organization (WHO)
4. HbA1C\<48 mmol/mol at screening
5. Subject must not use any regular prescribed medications (this excludes simple analgesia used as needed)
6. Subject must not use any over the counter supplements targeting metabolism
7. Subject must not have any acute or chronic disease which in the opinion of the investigator may affect the study outcome
8. Subject must not be a current smoker
9. No history of substance abuse or excess alcohol consumption (\>14 units/week)
10. Women of childbearing age must have a negative pregnancy test at screening and must not be breastfeeding
11. Women of childbearing age who are sexually active with a male partner must use highly effective contraceptive methods
You may not be if
1. Use of any regular medications
2. Use of illicit drugs
3. Use of any over the counter supplements affecting metabolism
4. Diagnosis of any acute / chronic disease
5. Current smoking or excess alcohol consumption (\>14 units/week)
6. Current pregnancy or lactation
7. Abnormal findings on physical exam or routine blood tests at screening (full blood count, urea and electrolytes, HbA1C, liver function tests)
8. Concurrent participation in another trial with an investigational product
