Lead Sponsor

NYU Langone Health

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. At least 18 years of age
•2. Undergoing primary ACL reconstruction with BPTB autograft for acute ACL tear, with or without concomitant meniscectomy
•3. Presenting within 2 weeks of injury and undergoing reconstruction within 8 weeks of injury

•1. History of blood-borne diseases including HIV, HBV, HCV, HTLV, or syphilis
•2. Pregnant
•3. Multiligamentous knee injury
•4. Concomitant meniscal repair, meniscal allograft transplantation, osteotomy, or repair of focal chondral defect (e.g., osteochondral autograft transfer system, osteochondral allograft, matrix-induced autologous chondrocyte implantation)
•5. Prior ipsilateral knee surgeries or injuries
•6. Primary sleep disorders including insomnia, sleep apnea, or restless legs syndrome
•7. Uncontrolled psychiatric disorders with sleep disturbance
•8. Night shift work
•9. Travel with time zone change within three weeks of surgery
•10. Systemic inflammatory disease
•11. Autoimmune disease
•12. Immunomodulatory drug use
•13. Chemotherapy within a year before surgery
•14. Intra-articular injection within 3 months before surgery

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