2. Prostate tumour biopsy specimens available at The Royal Marsden Hospital, Kingston Hospital, Epsom and St Helier Hospitals, St George's Hospital or Croydon University Hospital and \>2 primary tumour regions sampled
3. Received primary radical radiotherapy and androgen deprivation therapy and remains under follow up at The Royal Marsden Hospital
4. Willing and able to comply with blood sample collection
5. Capable of understanding and complying with the protocol requirements and has given written, dated and signed informed consent AND
6. Confirmed biochemical or radiological evidence of recurrent prostate cancer, and not yet received treatment for recurrent disease OR
7. FORECAST patients with confirmed biochemical or radiological evidence of recurrent prostate cancer who have received or are currently receiving treatment but are progressing (rising PSA and/or evidence of progressive disease on imaging), or have a PSA \>2ng/ml
You may not be if
1\. Patients who have had another malignancy (excluding non-melanoma skin cancer, in-situ or superficial bladder cancer) treated within the previous 5 years
Clareo Health | Exploring the Mechanisms and Dynamics of Clonal Evolution Leading to Recurrence in Prostate Cancer