huCART19-IL18 in CD19+ Cancers

Inclusion Criteria

• •1. Signed informed consent form
• •2. Documentation of CD19 expression on malignant cells by flow cytometry/IHC from a CLIA certified laboratory
• •NHL Patients: Within 6 months of physician-investigator confirmation of eligibility as long as there has been no intervening CD19 directed therapy since expression confirmed. Results outside of this window may be used, if there is no accessible tumor site and the subject did not receive intervening CD19 directed therapy since CD19 expression was confirmed.
• •CLL and ALL Patients: At time of most recent relapse. If the subject has subsequently received CD19-directed therapy since this result was obtained, repeating testing must be performed to determine eligibility.
• •3. Patients with relapsed disease after prior allogeneic SCT must meet the following criteria:
• •a. Have no active GVHD and require no immunosuppression b. Are more than 6 months from transplant at the time of physician-investigator confirmation of eligibility
• •4. Adequate organ function defined as:
• •a. Creatinine ≤ 1.6 mg/dl b. ALT/AST ≤ 3x upper limit of normal range c. Direct bilirubin ≤ 2.0 mg/dl, unless the subject has Gilbert's syndrome (≤3.0 mg/dl) d. Must have a minimum level of pulmonary reserve defined as ≤ Grade 1 dyspnea and pulse oxygen \> 92% on room air e. Left Ventricle Ejection Fraction (LVEF) ≥ 40% confirmed by ECHO/MUGA
• •5. Evidence of active disease within 12 weeks of physician-investigator confirmation of eligibility. .
• •6. Male or female age ≥ 18 years.
• •7. ECOG Performance Status that is either 0 or 1.
• •8. Subjects of reproductive potential must agree to use acceptable birth control methods.
• •9. Disease-specific criteria:
• •NHL Patients (Cohorts A and D):
• •i. Patients with any of the following diagnoses: Diffuse Large B-cell Lymphoma not otherwise specified (DLBCL NOS), germinal center or activated B-cell types;Primary Cutaneous DLBCL; Primary Mediastinal (thymic) Large B-cell Lymphoma; ALK+ Anaplastic Large B-cell Lymphoma; High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 rearrangements (i.e., "Double or Triple Hit"); High-grade B-cell Lymphoma, NOS; T-cell Rich B-cell Lymphoma; Transformed Follicular Lymphoma; or any aggressive B-cell lymphoma arising from indolent lymphoma.
• •1\. Patients must have either relapsed after, or be ineligible for, prior CAR T cell therapy, and meet one of the following criteria:
• •1. Relapsed/refractory disease after at least 2 prior lines of appropriate therapy; OR
• •2. Relapsed/refractory disease after autologous SCT; OR
• •3. Relapsed/refractory disease after allogeneic SCT. ii. Follicular lymphoma
• •1. Patients must have either relapsed after, or be ineligible for, prior commercial CAR T cell therapy; AND
• •2. Received at least 2 prior lines of appropriate therapy (not including single agent monoclonal antibody therapy) and progressed within 2 years after second or higher line of therapy.
• •iii. Mantle cell lymphoma
• •1. Patients must have either failed standard of care CAR T cell therapy (e.g., Tecartus™, etc) or other investigational CAR T cell product, OR be ineligible for standard of care Tecartus™; and
• •2. Patients must also meet one of the following criteria:
• •1. Relapsed/refractory disease after at least 2 prior lines of appropriate therapy, including a BTK inhibitor. Single-agent monoclonal antibody therapy does not count towards prior lines of therapy; OR
• •2. Relapsed/refractory disease after prior autologous SCT; OR
• •3. Relapsed/refractory disease after prior allogeneic SCT.
• •CLL Patients (Cohort B):
• •i. Chronic Lymphocytic Leukemia
• •1. Patients with relapsed/refractory disease after at least 2 prior lines of appropriate therapy; AND
• •2. Patients must have previously received or be intolerant to an approved BTK inhibitor and venetoclax, unless a BTK inhibitor or venetoclax is contraindicated.
• •ii. Large cell transformation of CLL (Richter's Transformation)
• •1\. Patients must be primary refractory or received at least 1 prior line of treatment for Richter's Transformation.
• •c. ALL Patients (Cohorts C and D): i. Patients with b-cell acute lymphoblastic leukemia. Note: Chronic myeloid leukemia (CML) lymphoid blast crisis is considered a sub-type of relapsed B-ALL, thus will be encompassed in our definition of B-ALL throughout; AND ii. Patients with 2nd or greater relapse or refractory disease as defined by one of the following criteria:
• •1. Recurrent disease in the blood or bone marrow identified morphologically, by IHC or flow; OR
• •2. Isolated CNS disease. Note: Patients with prior/current history of CNS3 disease will only be eligible for treatment if the CNS disease is responsive to therapy; OR
• •3. Recurrent extramedullary disease at other (non-CNS) sites if disease response can be assessed radiographically. Note: Patients with recurrent extramedullary disease do not need to have detectable blood or bone marrow involvement; OR
• •4. Any relapse after allogeneic SCT; OR
• •5. Patients with refractory disease as defined by one of the following:
• •1. Failure to achieve remission (\<5% bone marrow blasts or ongoing extramedullary or CNS disease) after 2 cycles of induction chemotherapy; OR
• •2. Patients that achieve remission but remain MRD+ after ≥2 cycles of induction chemotherapy.