This trial will recruit 500 hopitalized patients with AECOPD. The eligible participants will be randomly assigned to either PCT group or guideline group.The investigators aim to compare the efficacy and safety between PCT-gudied antibiotic therapy and guideline-guided antibiotic recommendations. The primary hypothesis is that PCT-guided antibiotic therapy will reduce the antibiotic prescription rate for AECOPD without negatively impacting the treatment success rate, compared with the GOLD guideline antibiotic recommendations.
Age
40–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Hospitalized patients with AECOPD
≥40 years of age
Able to understand and communicate to ensure the completion of the trial
Voluntary participation and provide written informed consent
You may not be if
Fever, Axillary temperature≥38°C
Pneumonia identified by X-Ray or CT of the chest
Severe respiratory failure requiring admittance to ICU
Concurrent infection at another site (e.g. urinary tract infection)
Immunosuppression secondary to chemotherapy, AIDS or malignant tumor of blood system
Comorbidities requiring corticosteroids (prednisone 30mg/d or equivalent more than 30 days )
Invasive mechanical ventilation
Patients with malignant tumors receiving chemotherapy or radiotherapy
