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Assessment of the efficacy of the multistage technique in the eradication of infection and achieving the union of traumatic infected femoral un-united shaft fractures in adult patients for one year follow up.
All cases will be treated by the induced membrane technique in two stages. In the first stage, thorough debridement of the infected bone and soft tissues and copious lavage will be done. After radical debridement, primary fixation will be done by either external fixation or antibiotic cement coated internally fixed implants.If there is a bone defect, it will be measured and filled with an antibiotic-impregnated (PMMA) cement spacer. The second stage procedure will be performed 4 to 8 weeks after the first one if soft tissue permits and only if there is no clinical or biochemical evidence of ongoing infection as indicated by normal white blood cell count, C-reactive protein, and erythrocyte sedimentation rate. It includes the exchange of the antibiotic cement spacer by a cancellous bone graft.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
Start Date
March 1, 2021
Primary Completion Date
August 1, 2022
Completion Date
October 1, 2022
Last Updated
December 23, 2020
40
ESTIMATED participants
Staged approach using antibiotic-cement impregnated PMMA spacer
PROCEDURE
Lead Sponsor
Assiut University
NCT06658379
NCT00726193
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