Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Alyatec
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subjects having signed the informed consent
Subjects affiliated to a social security scheme
Non-specific bronchial hyperreactivity (HRBNS) assessed by a positive methacholine test
FEV1 value \> 70% of theoretical FEV1 value
Asthma Control Test (ACT) ≥ 20/25 in 4 weeks prior to EEC exposure
Women of childbearing potential should have a negative pregnancy test throughout the study period with effective contraception.
Group A:
Cat allergic asthma (GINA 1, 2) associated with rhinitis and / or conjunctivitis symptoms triggered during an exposure to a cat.
Positive skin prick-test to cat allergen extract (wheal diameter \>3 mm compared to the negative control) Specific immunoglobulin E (IgE) for cat allergen \> 0.7 kU/L
Group B:
Mild allergic asthma (GINA 1 or 2) not sensitized to cat allergen with associated rhinitis and/or conjunctivitis.
Negative skin prick-test and specific IgE for cat allergen
Positive skin prick-test and specific IgE for another allergen.
You may not be if
Uncontrolled asthma, ACT asthma control questionnaire less than 20, in the last 4 weeks
Uncontrolled asthma 2 weeks after interruption of LABA
Long-term treatment by LABA, within 2 weeks prior to inclusion
Existence of a severe obstructive syndrome with FEV1 \<70% of the theoretical value
Obstruction triggered by spirometric evaluations
Hospitalization for asthma or exacerbation in the last 4 weeks
Subjects treated with oral corticosteroids in the 4 weeks prior to inclusion in the study
History of severe acute asthma requiring hospitalization in intensive care or intubation
Subjects treated with biotherapy in the 4 months prior to inclusion in the study
Presence of a cat at home, or daily exposure to cat allergens
Desensitization to cat allergens in the last 6 months
Active tobacco: plus 10 cigarettes / day or tobacco history plus 10 PA
Clareo Health | Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Cat Allergic Subjects With Asthma
