Università degli Studi del Piemonte Orientale Amedeo Avogadro
With
Ipsen
Azienda Ospedaliero Universitaria Maggiore della Carita
SIRN
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age \>18 years
Spasticity as a consequence of traumatic brain injury, spinal cord injury or MS (documented by clinical records)
Muscle tone graded at least 1+ on the modified Ashworth scale in the relevant joints of the affected limb(s), which requires medical intervention
BoNT naïve or pre-treated with any BoNT product. If previously treated with any BoNT, at least a 4 months interval between last injection and inclusion
You may not be if
Presence of fixed contractures or bony deformities in the affected limb
Changes in any oral antispastic medications or specific physiotherapy regimen \<4m before study entry or during the study.
Other neurological or orthopaedic conditions involving the affected limbs.
Sensitivity to BoNT-A or to its excipients
Other contraindications as given in the local SmPC for BoNT-A
