Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation

Inclusion Criteria

• •age ≥ 18 years
• •Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• •histologically confirmed primary adenocarcinoma of the colon or rectum
• •CLM considered unresectable or not amenable to percutaneous ablation
• •existent tissue samples from a standard of care biopsy of the target tumor within 42 days prior to treatment OR clinical indication for biopsy at the time of the treatment under the institutional guidelines for progression of disease.
• •adequate blood cell counts (WBC \> 1.5 x 109/L, platelet count \> 50 x 109/L)
• •adequate renal function (creatinine \< 1.5 mg/dL)
• •total bilirubin level ≤ 1.5 mg/dL
• •A. patients not amenable to surgery or thermal ablation