A First-in-human Study to Investigate the Safety, Tolerability and Pharmacokinetics of MAS825 in Healthy Volunteers

Exclusion Criteria

• •Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant
• •A history of ongoing, chronic or recurrent infectious disease, or evidence of tuberculosis infection as defined by a positive QuantiFERON TB-Gold test
• •Fasting LDL \> 160 mg/dL, at screening.
• •Subjects in cohorts D1 and D2 (Japanese cohorts) must be of first to third generation Japanese ethnic origin.