Weight Regain Treatment Post-Bariatric Surgery

Exclusion Criteria

• •Has a predisposition to seizures (e.g., subject with a history or evidence of seizure disorder, febrile seizures during childhood, brain tumor, cerebrovascular disease, or significant head trauma; has a family history of idiopathic seizure disorder or is currently being treated with medications or treatment regimens that lower seizure threshold).
• •Has a history of anorexia nervosa or history of bulimia nervosa.
• •Is currently taking a medication that is a contraindication to NB medication (e.g., MAOI, opiates).
• •Is currently using other medications for weight loss.
• •Has a history of allergy or sensitivity to bupropion or naltrexone.
• •Has a co-existing psychiatric condition that requires hospitalization or more intensive treatment (such as bipolar mood disorders, psychotic illnesses, or severe depression)
• •Has untreated hypertension with a seated systolic blood pressure \> 160 mmHg, diastolic blood pressure \> 100 mmHg, or heart rate \> 100 beats/minute.
• •Has a history of congenital heart disease, cardiovascular disease, cardiac arrhythmias requiring medication, or a history of cerebrovascular pathology including stroke.
• •Has current uncontrolled hypertension.
• •Has current uncontrolled Type I or Type II diabetes mellitus.
• •Has untreated hypothyroidism with a TSH \> 1.5 times the upper limit of normal for the test laboratory with repeat value that also exceeds this limit.
• •Has gallbladder disease.
• •Has a history of severe renal, hepatic, neurological, chronic pulmonary disease, or any other unstable medical disorder.
• •Has a recent history of drug or alcohol dependence (since having bariatric surgery).
• •Is currently in active treatment for eating or weight loss.
• •Is currently participating in another clinical study in which the subject is or will be exposed to an investigational or a non-investigational drug or device.
• •Is breast-feeding or is pregnant or is not using a reliable form of birth control.
• •Reports active suicidal or homicidal ideation.