Donepezil Versus Non-drug Treatment in Alzheimer's Disease.

Exclusion Criteria

• •Other cause of dementia.
• •Previous use of symptomatic treatment for Alzheimer's disease.
• •Hypersensitivity to donepezil hydrochloride or to any of the excipients listed in the SPC.
• •Cardiological contraindication after possible opinion of a cardiologist, at the initiative of the investigator, in particular bradycardia, sinus disease or other supra-ventricular conduction abnormalities such as sinoatrial or atrioventricular block.
• •Taking concomitant medications known to prolong the interval QTc
• •Patients at particular risk of ulcer, known ulcer disease or receiving concomitant treatment with non-steroidal anti-inflammatory drugs.
• •Patient at risk of urinary retention.
• •History of epileptic disease.
• •History of neuroleptic malignant syndrome.
• •History of asthma or obstructive bronchopulmonary disease.
• •Severe hepatic impairment.
• •Taking one of the following treatments:
• •* CYP3A4 inhibitors, such as ketonazole.
• •* 2D6 inhibitors, such as quinidine.
• •* CYP3A4 inhibitors, such as itraconazole and erythromycin.
• •* CYP2D6 inhibitors, such as fluoxetine.
• •* Enzyme inducers such as rifampicin, phenytoin, carbamazepine.
• •* Antiarrhythmic class IA agents
• •* Antiarrhythmic class III agents
• •* other Antipsychotics such as phenothiazine, sertindole, pimozide, ziprasidone.
• •* some antiobiotics such as clarithromycine, erythromycine, levofloxacine, moxifloxacine.
• •Participation in another interventional study.