Diffusion-Weighted MRI for Diagnosis of Multifocal, Multicentric Breast Cancer

Primary objective: to compare the diagnostic performance of DCE MRI vs combination of DWI and DCE MRI for detection of multifocal, multicentric breast cancer in patients planning for breast conservation surgery Detailed Description * This is a multicenter, intraindividual comparative cohort study. * A total of 580 women with newly diagnosed breast cancer will be enrolled in this study. * Each eligible woman with newly diagnosed invasive breast cancer will undergo DCE MRI and DWI at a 3T MR scanner. * Contrast-enhanced MRI and DWI will be interpreted independently according to the Breast Imaging Reporting and Data System (BI-RADS) and likelihood of malignancy (Score range, 0%-100%) by trained radiologists. * Multifocal breast cancer is defined as presence of more than 2 separate (≥1.0cm) foci of breast cancer in the same quadrant or within 5 cm of the primary lesion. * Multicentric cancer is defined as two or more synchronous ipsilateral neoplasm located in different quadrant or beyond 5 cm from the primary lesion. * BI-RADS final assessment score of 4 or 5 are considered to be positive. * Pathology of core or surgical biopsy and 2 year follow up is the reference standard.