Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects

Exclusion Criteria

• •Any clinically significant concomitant disease or condition (including treatment for such conditions) that, in the opinion of the Investigator, could either interfere with the study drug, pose an unacceptable risk to the subject, or compromise interpretation of study data
• •Gilbert's syndrome
• •Pre-existing condition interfering with normal gastrointestinal anatomy or motility, hepatic and/or renal function that could interfere with the absorption, metabolism, and/or excretion of study drug
• •eGFR \<60 mL/min/1.73 m2 based on Modification of Diet in Renal Disease (MDRD) equation
• •Received an investigational drug or device from another study within 30 days (or 5 half-lives, whichever is longer) prior to study drug administration
• •In healthy subjects with normal hepatic function:
• •* Systolic blood pressure outside the range of 90 to 150 mmHg, diastolic blood pressure outside the range of 40 to 95 mmHg or heart rate outside the range of 40 to 100 beats per minute (bpm)
• •* History of regular alcohol consumption exceeding 7 drinks/week for females or 14 drinks/week for men (1 drink = 5 ounces of wine or 12 ounces of beer or 1.5 ounces of hard liquor) within 6 months prior to screening
• •In subjects with hepatic impairment:
• •* Any non-hepatic acute or chronic condition (including, but not limited to, poorly controlled diabetes and encephalopathy Grade ≥3) that, in the opinion of the Investigator, would limit the subject's ability to complete and/or participate in the study
• •* Acute exacerbation of HI or unstable hepatic function, as determined by the Investigator, 30 days prior to study drug administration
• •* Has had a Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure performed