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Methoxyflurane and Fentanyl in LBNP | Clinical Trials | Clareo Health

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COMPLETEDPhase 4NCT04641949

Methoxyflurane and Fentanyl in LBNP

The study is a single-centre, placebo-controlled, crossover study on healthy volunteers aiming to explore non-inferiority of methoxyflurane and fentanyl compared to placebo on the tolerance to hypovol...

Lead sponsor: Oslo University Hospital•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Oslo University Hospital

The study will explore the effects of fentanyl and methoxyflurane versus placebo (NaCl; saline) on the hemodynamic response to hypovolemia in healty volunteers. Hypovolemia will be induced in the "lower body negative pressure" model. XX healthy volunteers will be exposed to inhaled methoxyflurane, 3 ml or intravenous fentanyl, XX mg or placebo in a randomized order (cross-over) at least 3 days apart.

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Must be at least 18 years of age.
•Must be below 65 years of age.
•Signed informed consent and expected cooperation for the study and follow up must be obtained and documented according to ICH GCP, and national/local regulations.

Exclusion Criteria

•Any medical condition limiting physical excertional capacity or requiring regular medication (allergy and oral contraceptives excepted)
•Pregnancy
•History of syncope (syncope of presumed vasovagal nature with known precipitating factor excepted)
•Any known cardiac arrhythmia
•History of renal disease
•History of liver disease
•Previous substance abuse
•Allery or known serious side-effects to opioids or methoxyflurane

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 30, 2022Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment15

Start dateNov 2020

Last updatedJun 30, 2022

Condition

Hypovolemia Cardiac Output, Low Analgesia

Locations shown

Oslo University Hospital

Oslo

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 30, 2022Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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