Biomarkers of Endometrial Receptivity

Exclusion Criteria

• •genetic disease
• •metabolic and/or endocrine disorders
• •polycystic ovary syndrome (defined by the Rotterdam criteria)
• •women with prior diagnosis of endometriosis or adenomyosis
• •previous gynecological/pelvic surgery except for salpingectomy
• •repeated spontaneous abortions (two or more)
• •previously less than 5 oocytes and/or serum anti-Mullerian hormone value \< 1.0 mIU/ml or more than 20 oocytes, milli-International unit (mIU)
• •previous ovarian hyperstimulation syndrome (OHSS)
• •presence of any structural abnormality of the reproductive system
• •donor oocyte cycles
• •severe male factor infertility \< 5 million sperm/mL
• •low response to stimulation
• •endometrium \< 8 mm at the day of human chorionic gonadotropin (hCG) or ET
• •number of retrieved oocytes 5 - 20
• •low fertilization capacity (rate of fertilization \< 20% and late ICSI following IVF fertilization failure)
• •OHSS
• •IVF cycle cancelled before ET
• •other than easy one high-quality blastocyst transfer (at least grade 3BB)
• •genetic disease
• •metabolic and/or endocrine disorders such as diabetes, metabolic syndrome, and thyroid disorders
• •polycystic ovary syndrome (defined by the Rotterdam criteria), hyperprolactinaemia
• •women with prior diagnosis of endometriosis or adenomyosis
• •previous gynecological/pelvic surgery except for salpingectomy
• •repeated spontaneous abortions (two or more)
• •previously less than 5 oocytes and/or serum anti-Mullerian hormone value \< 0.5 mIU/ml in the stimulated cycle
• •previous OHSS
• •presence of any structural abnormality of the reproductive system
• •severe male factor infertility \< 5 million sperm/mL in the stimulated cycle
• •number of retrieved oocytes 5 - 20 in the stimulated cycle
• •low fertilization capacity (rate of fertilization \< 20% and late ICSI following IVF fertilization failure)
• •endometrium less than 8 mm at the day of thawing and transfer indication
• •thawed blastocyst cycle cancelled before ET
• •other than easy one best quality frozen/thawed blastocyst transfer (at least grade 3BB)