Age

18–65

Sex

ALL

Healthy volunteers

Not accepted

≥ 18 and ≤ years
Good performance status, ECOG 0 or 1
Resected adenocarcinoma in colon or rectum (R0 resection)
Unresectable liver metastases
No extrahepatic disease
Normal blood tests
Response to ≤ 2 lines of chemotherapy (RECIST criteria)
≥ 1 year period since diagnosis of colorectal cancer to enrolment in liver transplant waiting list
Signed informed consent

Body mass index ≥ 30
Positive HIV or HCV
Pregnancy at the time of inclusion
BRAF mutated status
Deterioration of general condition (10% weight loss in the prior 6 months)
Other malignancy with disease free survival \< 5 years
Concomitant or prior extrahepatic metastases (histologically or radiologically proved), even if surgically resected.
Palliative resection of primary colorectal adenocarcinoma
Liver metastases size \> 5 cm (in the last imaging technique)
CEA \> 80 ng/ml (at time of enrolment in waiting list)
No neoadjuvant chemotherapy treatment
General contraindication to liver transplantation

Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases