A potential subject who meets any of the following criteria will be excluded from participation in this study:

No mpMRI performed prior to prostate biopsy or radical prostatectomy

A history of chemotherapy for PCa or currently being treated with chemotherapy for PCa.

A patient history that includes any of the following prostate related interventions:

* Brachytherapy or external radiotherapy for PCa;

* Focal therapy for prostate cancer;

* Prostate biopsy within the last 30 days.

Hormonal therapy for prostate cancer within the last six months

A patient history with a cardiac right to left shunt.

Current treatment with dobutamine

Known severe pulmonary hypertension (pulmonary artery pressure \>90 mmHg), uncontrolled systemic hypertension or respiratory distress syndrome

Incapable of understanding the language in which the patient information is given.

Threedimensional Multiparametric Ultrasound for Prostate Cancer Detection