Multimodal Biomarkers for Diagnosis and Prognosis in VCI

Exclusion Criteria

• •\-
• •I. Vascular cognitive impairment patients:
• •1. Have other illnesses, including people with drug / alcohol abuse / addictivity within three months.
• •2. Patient cannot accept brain magnetic resonance imaging or 11C-PiB PET, such as agitation and inability to cooperate, allergy to contrast agents, hemodynamic instability (blood pressure, pulse, or blood oxygen is not in the normal range), and a heart rhythm regulator has been implanted , Have ever undergone intracranial aneurysm clamp surgery, claustrophobia and hemodynamic instability.
• •3. Pregnant woman or intends to be pregnant in the near future.
• •4. Patient who is breast feeding or intends to.
• •5. Allergic to 11C-PiB, or with severe drug allergy history.
• •6. Patient or the family refuses to participate in the study.
• •II. Alzheimer's disease (AD) patients:
• •1. Have other illnesses, including:
• •1. Cognitive disorders caused by cerebrovascular diseases (the decline in cognitive function is closely related to the time of stroke, multiple large-scale necrosis, and severe white matter lesions).
• •2. The main manifestation of dementia is Lewy body dementia
• •3. Symptoms are behavioral variation of frontotemporal dementia.
• •4. The symptoms are obviously semantic progressive aphasia.
• •5. Symptoms are not fluent in primary progressive aphasia.
• •6. Other comorbidities that affect cognitive function (including other active neurological diseases, or non-neurological diseases but the disease or the treatment used will affect cognitive function)
• •2. Patient cannot accept brain magnetic resonance imaging or 11C-PiB PET, such as agitation and inability to cooperate, allergy to contrast agents, hemodynamic instability (blood pressure, pulse, or blood oxygen is not in the normal range), and a heart rhythm regulator has been implanted , Have ever undergone intracranial aneurysm clamp surgery, claustrophobia and hemodynamic instability.
• •3. Pregnant woman or intends to be pregnant in the near future.
• •4. Patient who is breast feeding or intends to.
• •5. Allergic to 11C-PiB, or with severe drug allergy history.
• •6. Patient or the family refuses to participate in the study.
• •III. Normal controls:
• •1. Patient cannot accept brain magnetic resonance imaging or 11C-PiB PET, such as agitation and inability to cooperate, allergy to contrast agents, hemodynamic instability (blood pressure, pulse, or blood oxygen is not in the normal range), and a heart rhythm regulator has been implanted , Have ever undergone intracranial aneurysm clamp surgery, claustrophobia and hemodynamic instability.
• •2. Pregnant woman or intends to be pregnant in the near future.
• •3. Patient who is breast feeding or intends to.
• •4. Allergic to 11C-PiB, or with severe drug allergy history.
• •5. Patient or the family refuses to participate in the study.
• •6. high risk as assessed by a doctor.