Clinical and Cost-effectiveness of Fluoride Varnish Versus Resin Based Sealant

A Cochrane systematic reviews found low quality evidence supporting Current practice guidelines that recommend the use of Resin based fissure sealant over Fluoride varnish in prevent dental caries. However, they did not address the cost-effectiveness, A more recent systematic review and meta-analysis concluded that no statistical significance difference between Resin based fissure sealant and Fluoride varnish with a high-quality evidence in prevent dental caries. This trial will measure cost effectiveness and clinical effectiveness for resin fissure sealant and fluoride varnish.