Lead Sponsor

University of Colorado, Denver

Age

50 - 70 years

Sex

ALL

Healthy Volunteers

No

•Age 50-75 years old
•Serum bicarbonate 16-22 mEq/L on 2 separate measurements (at least 1 day apart)
•CKD stage 3b or 4 at time of screening (eGFR 15-44 ml/min/1.73m2)
•Blood pressure \<130/80 mm Hg prior to randomization
•Use of angiotensin converting enzyme inhibitor or angiotensin receptor blocker
•Stable anti-hypertensive regimen for at least one month prior to randomization
•Montreal Cognitive Assessment Score \> 24
•No history of stroke
•No history of dementia
•No history of neurologic disease
•Able to provide consent

•Use of chronic daily oral alkali within the last 3 months (including sodium bicarbonate, calcium carbonate or baking soda)
•Uncontrolled hypertension
•Serum potassium \< 3.3 or ≥ 5.5 mEq/L at screening
•New York Heart Association Class 3 or 4 heart failure symptoms, known EF ≤30%, or hospital admission for heart failure within the past 3 months
•Factors judged to limit adherence to interventions
•Anticipated initiation of dialysis or kidney transplantation within 12 months
•Current participation in another research study
•Pregnancy or planning to become pregnant or currently breastfeeding
•Chronic use of supplemental oxygen