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COMPLETEDNA

The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF

The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of Repeated Implantation Failure.

NCT04597463•National and Kapodistrian University of Athens

Summary

The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates

Detailed Description

After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.

Eligibility

Age

25 - 42 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Women with RIF under 42 years old
•BMI 20-30
•Normal endometrial cavity
•FSH \<15 IU/L
•Absence of immunological or hematological disorder

Exclusion Criteria

•women over 42 years old
•FSH\>15 IU/L
•women with chronic immunological or hematological disorder
•stage III or IV of endometriosis
•women with pathology concerning the endometrial cavity
•women with a medical history of adnexectomy or oophorectomy

Locations (1)

National and Kapodistrian University of Athens

Athens, Greece

Key Dates

Start Date

December 2, 2017

Primary Completion Date

September 2, 2020

Completion Date

October 2, 2020

Last Updated

October 27, 2020

Enrollment

ACTUAL participants

Conditions

Endometrial InjuryHysteroscopyRepeated Implantation Failures

Interventions

Endometrial injury

PROCEDURE

Ultrasound Guidance of Office Hysteroscopy in Patients With History of Failure of Office Hysteroscopy Due to Cervical Stenosis.

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Hysteroscopy

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RECRUITINGNA

UTERINE EVALUATION FOR THE IDENTIFICATION OF PATHOLOGY. This Study Will Compare the Intrauterine Pathology Detection Rate Between Standard of Care Hydrosonography, and a New Visual Saline Infusion Device Providing Direct Visualization of the Uterus.

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HysteroscopyHysteroscopy Technique+5 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 27, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF

Inclusion Criteria

Exclusion Criteria

Ultrasound Guidance of Office Hysteroscopy in Patients With History of Failure of Office Hysteroscopy Due to Cervical Stenosis.

UTERINE EVALUATION FOR THE IDENTIFICATION OF PATHOLOGY. This Study Will Compare the Intrauterine Pathology Detection Rate Between Standard of Care Hydrosonography, and a New Visual Saline Infusion Device Providing Direct Visualization of the Uterus.

Targeted Lidocaine Infusion for Pain Reduction in Office Hysteroscopy

Green Hysteroscopy

The Effect of Music on Pain and Anxiety During Diagnostic Outpatient Hysteroscopy in Postmenopausal Women

Hysteroscopic Evaluation and the Clinical Outcomes of Vaginal Repair of Cesarean Section Scar Defects