Pharmacokinetics of CBD From a Hennep Extract

Exclusion Criteria

• •Is currently suffering from a disease
• •Has had any gastrointestinal condition/disease within the 3 months prior to the intervention
• •Haemoglobin (Hb) level \< 8.5 mmol/L for men and \< 7.5 for women
• •Has used medication in the two months before and/or during the intervention. Oral contraceptives and occasional use of NSAIDs or paracetamol (\<max 3 a week on average) is allowed.
• •Reported weight loss or weight gain of \> 2 kg in the month prior to the intervention
• •Use of herbal dietary supplements (excluding vitamins and minerals) or grapefruit products, 2 weeks before the first testday and in between the testdays.
• •Allergic to products that are provided as part of the standardised diet
• •Following a specific diet (e.g. vegetarian, gluten free)
• •(History of) drug abuse, in this case meaning \>1 x per month use of recreational drugs
• •Cannabis use in the 14 days preceding the first test day.
• •Smoking
• •Alcohol consumption of \>10 standardised glasses per week.
• •Recent or planned blood donation (\<3 month prior to first study day or during intervention)
• •Have been pregnant or breastfeeding in the last 6 months, or plan to become pregnant during the study
• •(If applicable) In case of using contraceptives, not willing to delay the break between two packets of the conception pill during which a woman gets her period during the study period.
• •Personnel of Wageningen University, department of Human Nutrition and Health,
• •Currently participating in other research or was participating in another study within 1 month of the intervention or within 3 months if invasive procedures were used.