Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Central South University
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Age between 18 and 60 years.
2. Meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for a current major depressive episode.
3. Demonstrating an inadequate response to antidepressant treatment lasting at least 2 weeks, at the minimum effective dose for antidepressants. Inadequate response is defined as a \< 20% change in the Hamilton Depression Rating Scale-17 (HAMD-17) score or as per patients' self-report in the antidepressant treatment questionnaire. Minimum effective doses for some commonly used classes of antidepressants include:
* Sertraline: \>50mg
* Fluoxetine: \>20 mg
* Citalopram: \>20 mg
* Escitalopram: \>10mg
* Venlafaxine: \>75 mg
* Duloxetine: \>50 mg
4. HAMD-17≥17; Clinical Global Impression-Severity (CGI-S) score ≥4.
5. Education level of at least 6 years, with the ability to independently complete all scales and assessments.
6. Agreement from primary healthcare providers and patients to maintain current antidepressant treatment while adding agomelatine.
You may not be if
1. Meeting criteria for other psychiatric disorders according to DSM-IV (except generalized anxiety disorder), such as schizophrenia, bipolar disorder, or mental disorders related to alcohol and drug dependence.
2. Current or previous history of brain organic diseases or loss of consciousness for more than 5 minutes.
3. Current or previous history of major physical diseases (including rheumatic immune system diseases, endocrine and metabolic diseases, nervous system diseases, etc.).
4. Current serious suicidal ideation or suicide attempt.
5. Pregnancy or lactation in women.
6. Color blindness (which would hinder neurocognitive testing).
7. Use of anticoagulants (e.g., heparin, warfarin), glucocorticoids, or treatment for thyroid diseases in the past 3 months.
8. Having received any neurocognitive assessment similar to this study in the past 12 months.
9. Positive urine drug screening results or abnormal thyroid function test.
10. Liver function tests showing transaminase (ALT and AST) levels 2 times above the upper limit of the normal range.
11. Electrocardiogram examination revealing a QTc ≥ 430 ms in males or QTc ≥ 450 ms in females.
Clareo Health | A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With Agomelatine
