The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke

Exclusion Criteria

• •Presence of dementia diagnosis before the index stroke or at the initial screening History of vascular MCI (VaMCI)
• •The Chinese version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) score \>=104 \[24\] at the initial screening.
• •Presence of large infarction or lobar encephalomalacia on brain CT or MRI.
• •Severe language impairment precluding cognitive assessments, defined as a score of 3 points in the language score of the National Institute of Health Stroke Scale.
• •Life expectancy less than 1 year.
• •Clinically significant abnormal laboratory values.
• •Clinically significant or unstable medical or psychiatric illness.
• •Epilepsy history.
• •Cognitive impairment resulting from trauma or brain damage.
• •Substance abuse or alcoholism in the past 1 year
• •Pregnant or becoming pregnant during the study (as documented by pregnancy testing at screening or at any date during the study according to the PI discretion) or current breast feeding.
• •History of allergy to 18F-labelled radionucleic agents, \[18F\]AV-45 or \[18F\]THK-5351.
• •Subjects having high risks for the study according to the PI discretion.