Neoadjuvant Treatment of Early Triple-negative Breast Cancer With Chidamide and Chemotherapy

Exclusion Criteria

• •1. No measurable lesions, such as pleural or pericardial effusion, ascites, etc;
• •2. Major surgical procedures or significant trauma were performed within 4 weeks before enrollment, or patients were expected to receive major surgical treatment (not related to breast cancer);
• •3. Previously treated with chemotherapy or HDAC inhibitors (including romidepsin, vorinostat, belinostat, and panobinostat，etc);
• •4. Have allergic history to the components of this regimen;
• •5. Treated with radiotherapy within 4 weeks before admission;
• •6. Have a history of immunodeficiency, including HIV positive, or other acquired or congenital immunodeficiency diseases, or have a history of organ transplantation;
• •7. Uncontrolled cardiovascular diseases, history of clinically significant QT interval prolongation, or QTc interval \> 450 ms at screening;
• •8. Abnormal liver function \[total bilirubin \> 1.5 times of the upper limit of normal value; ALT / AST \> 2.5 times of upper limit of normal value for patients without liver metastasis ; ALT / AST \> 5 times of upper limit of normal value for patients with liver metastasis \], abnormal renal function (serum creatinine \> 1.5 times of upper limit of normal value);
• •9. Pregnant, lactating or fertile women with a positive baseline pregnancy test; or subjects of childbearing age who are not willing to take effective contraceptive measures during the study period and at least 8 weeks after the last administration;
• •10. According to the judgment of the investigator, there are some concomitant diseases (such as severe hypertension, diabetes, thyroid disease, active infection, etc.) that seriously endanger the safety of patients or affect patients to complete the study;
• •11. A clear history of epilepsy or dementia, including neurological disorders;
• •12. The investigator determined not suitable to participate in this study.