Validation of a Biomathematical Model to Help Identify the Parameters of Flexible Insulin Therapy

Exclusion Criteria

• •1. Patient with type 2 diabetes or secondary diabetes
• •2. Patient with any serious medical condition that may affect participation in the study,
• •3. Patient benefiting from a legal protection measure,
• •4. Woman who is pregnant or likely to become pregnant during the course of the study, i.e., a lack of effective contraception in women of childbearing age,
• •5. Breastfeeding,
• •6. Psychological and/or physical condition that may affect the proper monitoring of study procedures,
• •7. Severe hypoglycemia leading to convulsions or loss of consciousness within the last 12 months,
• •8. Decreased hypoglycemic feelings (as judged by the clinician),
• •9. Impaired renal function (creatinine clearance calculated by CKD-EPI \< 30mL/min),
• •10. Patient who has had a pancreas transplant or pancreatic islets,
• •11. Persons with severe uncorrected hearing and/or visual acuity problems,
• •12. Insulin resistance defined by daily insulin requirements \> 1 U/kg/day in the week prior to inclusion,
• •13. Patient treated with oral corticosteroid therapy.